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Shake It Up Australia Foundation for Parkinson’s Research

Contact

Name: Vicki Miller

Position: General Manager - Strategic Partnerships

Email: vicki@shakeitup.org.au

Website: https://www.shakeitup.org.au

Address

PO Box 710

Spit Junction NSW 2088

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Our Mission / Objective

Shake It Up Australia Foundation is a not-for-profit organisation established in 2011 and in partnership with The Michael J. Fox Foundation (MJFF) promotes and funds Parkinson’s disease research in Australia aimed at better treatments and ultimately a cure.

The foundation was established by Clyde Campbell, a father of three and business owner who was diagnosed with Parkinson’s disease in 2009 at the age of 44.

To date the foundation has co-funded over $10.4 Million into Australia Research projects targeted at finding better treatments and ultimately a cure for Parkinson’s.

Most of the projects we support are funded on a 50/50 basis with The Michael J. Fox Foundation which means that we are effectively able to double the reach of the funds we raise.

Together with our partners The Michael J. Fox Foundation, we are the largest non-government funders of Parkinson’s research across multiple institutes in Australia.  It is only through international collaboration that we will find a cure for Parkinson’s.

Our Services

As the country’s leader in strategic Parkinson’s research funding we are excited about the talent we have in our Australian institutes and the prospect that their work will take us closer to a cure.

OUR FUNDING MODEL
100% of your donation goes to Parkinson's research

  • 100% of your donation goes to research targeted at finding better treatments and ultimately a cure for Parkinson’s disease.

(This is made possible by our founding directors’ commitment to fund all administration costs of the foundation)

  • Our partnership with the Michael J. Fox Foundation for Parkinson’s Research ensures efficiency and transparency.
    Key benefits to our research grants are:
  • Internationally Competitive
  • Non Redundant
  • Strategically Managed

Our Beneficiaries

Our partnership with MJFF gives confidence that the research we are funding in Australia is internationally competitive. All funded research is first assessed and validated by the expert panel of scientists at MJFF to eliminate redundancy of research around the globe. Once approved the research projects are monitored and benchmarked by a team of formally trained PhDs and business-trained project managers. This includes the periodic release of funds in line with the approved grant and on the basis of reported results.

Shake It Up have funded projects at:

  • The Garvan Institute for Medical Research
  • Neuroscience Research Australia (NEURA)
  • The  University of Sydney
  • Brain and Mind Institute
  • Macquarie Neurology
  • The Florey Institute
  • La Trobe University
  • University of Queensland

Projects in Progress

As the country’s leader in strategic Parkinson’s research funding we are excited about the talent we have in our Australian institutes and the prospect that their work will take us closer to a cure.

Through our unique partnership we know our research is strategic, non-redundant and internationally competitive. Listed below are the projects we have funded and with your support we look forward to funding many more in the future.

Current projects

 

Linked Clinical Trial – NSW

Professor Simon Lewis

Professor Simon Lewis

Award Date: April 2018

Duration: 3 Years

Institution:  Brain and Mind Institute,  University of Sydney

Researchers:

  • Professor Simon Lewis, Professor Dominic Rowe, Professor Glenda Halliday

 

The protocol for this trial will be  for four drugs and one placebo in patients with more established Parkinson’s as well as validating disease biomarkers that could be used to evaluate the efficacy of future therapeutic treatments

Linked Clinical Trial – Queensland

Associate Professor John O'Sullivan

Associate Professor John O’Sullivan

Award Date: April 2018

Duration: 3 Years

Institution:  The University of Queensland

Researchers:

  • Associate Professor John O’Sullivan

This project is a collaboration between the University of Queensland, Shake It Up, Queensland Government, The Wesley Research Institute, Griffith University and The Cure Parkinson’s Trust.

The protocol for this study is to trial two re-purposed drugs against two placebo groups. The overall approach of the intended trial is to rapidly screen existing drugs that are licensed and used already in clinical practice for other indications to determine whether they are worth transitioning to Phase III, multi-centre, randomised, placebo-controlled, double blind trials. If successful, such trials would facilitate a change in the indication of already licensed medications to allow their use as disease modifying treatments for Parkinson’s disease.

 

Using MJF-14 antibody to uncover novel alpha-synuclein pathology in Parkinson’s disease and MSA

Professor Glenda Halliday phD

Award Date: December 2017

Duration: 2 Years

Institution:  The University of Sydney

Researchers:

  • Professor Glenda Halliday phD

I) Assess the presence of aggregated alpha-synuclein in inclusions and as diffuse oligomers in PD (Braak stage 4 and 6) and MSA (MSA-p and MSA-C) post-mortem tissues by IHC and IF using
multiple antibodies selected for alpha-synuclien including MJF-14
2) Assess the presence of aggregated alpha-synuclein in inclusions and as diffuse oligomers in PD and MSA post-mo1iem tissues by MJF-14 proximity ligation assay and fF analyses
3) Assess the correlation between the cytopathology of oligodendrocytes, astrocytes and neurons
4) Assess specific protein changes associated with inclusion formation, myelination and mitochondria

Objective Measurement for population screening therapy optimisation and target validation

Professor Malcolm Horne

Award Date: December 2017

Duration: 2 Years

Institution:  Florey Neurosciences Institute

Researchers:

  • Professor Malcolm Horne

Objective measurement in Parkinson’s Disease (PD), offers significant advantages for clinical management and the clinical validation of new therapies.

The Parkinson’s/Personal KinetiGraph™ (PKG™) System provides continuous, objective measurement of movement disorder symptoms in everyday environments, including bradykinesia (BK), dyskinesia (DK) and tremor. The PKG™ system consists of a wearable data logger, proprietary algorithms for data analyses and
intuitive data presentation for clinicians (the PKG™ report). The PKG system was TGA Registered in 2009, CE Marked in 2010, and FDA cleared in 2014.

This project seeks to demonstrate that the use of targets will identify PwP with uncontrolled motor features of PD and that treating these subjects according to Treatment Guidelines will bring these scores into target and lead to better clinical and quality of life outcomes. Treatment Guidelines are a critical tool to assist non-specialist clinicians, such as general neurologists and geriatricians, to more effectively manage PD.

Validation of these treatment targets will also advance the evidence-based application of objective measurement and targets for clinical validation of new therapies.

How Does LRRK2 Activity Affect Inflammatory Signaling in Parkinson’s Disease?

Nic Dzamko - University of Sydney Parkinson's research

Dr Nicolas Dzamko PhD – University of Sydney

Award Date: February 2017

Duration: 12 months

Institution:  The University of Sydney

Researchers:

  • Dr Nicolas Dzamko PhD

Differences in the leucine-rich repeat kinase 2 (LRRK2) gene can increase the risk of developing Parkinson’s disease (PD), and there is an abundance of the LRRK2 protein in blood immune cells that regulate inflammation. This project will determine if genetic differences in LRRK2 affect inflammation in PD.

Find out more

Peripheral Inflammatory Cytokine Profiling in Parkinson’s Disease

Nic Dzamko - University of Sydney Parkinson's research

Dr Nicolas Dzamko PhD – University of Sydney

Award Date: February 2017

Duration: 12 months

Institution:  The University of Sydney

Researchers:

  • Dr Nicolas Dzamko PhD

The contribution of inflammation to Parkinson’s disease (PD) is increasingly being recognised. However, the stage of the disease in which inflammation is prevalent and/or important remains unclear. Our recent work suggests that inflammation may be increased early in the course of PD.

Find out more

Pharmacological Targeting of Proinflammatory Kinase Signaling in Parkinson’s Disease

Dr Richard Gordon research into Parkinson's disease

Dr Richard Gordon

Award Date: November 2016

Duration: 12 months

Institution:  UQ’s School of Biomedical Sciences

Researchers:

  • Dr Richard Gordon

The research collaboration comprises researchers from across UQ, including Dr. Richard Gordon and Associate Professor Woodruff from the School of Biomedical Sciences, Dr John O’Sullivan from The School of Medicine and RBWH and Professor Matt Cooper and Dr Kate Schroder from the Institute for Molecular Bioscience.

Find out more

Blocking Inflammasome-induced Neuroinflammation in Parkinson’s Disease with a Potent, Orally Available Small Molecule

Matthew Cooper - receives funding from Shake It Up for Parkinson's research

Matthew Cooper, PhD

Award Date: September 2016

Duration: 12 months

Institution:  NHMRC Principal Research Fellow and Professor of Chemistry & Structural Biology at University of Queensland

Researchers:

  • Matthew Allister Cooper, PhD

Find out more

FLUROSCENCE TAGGING OF ENDOGENOUS LRRK2 TO ENABLE IN VIVO IMAGING IN MICE AND DIFFERENTIATED HUMAN IPS CELLS

Dzamko2

Dr Nicolas Dzamko

Award Date: March 2016

Duration: 12 months

Institution:  Neuroscience Research Australia

Researchers:

  • Nicolas Dzmako

Find out more

DEVELOPMENT OF A NOVEL TRACER FOR IMAGING A-SYNUCLEIN IN VIVO

Victor Villemagne

Award Date: March 2016

Duration: 12 months

Institution:  The Florey Institute of Neuroscience and Mental Health

Researchers:

  • Victor Villemagne, MD
  • Kevin Barnham, PhD

Find out more

UNDERSTANDING LRRK2 S910/S935 PHOSPHORYLATION IS IMPORTANT FOR THERAPEUTIC LRRK2 INHIBITOR DEVELOPMENT.

Dzamko2

Dr Nicolas Dzamko

Award Date: March 2016

Duration: 12 months

Institution:  Neuroscience Research Australia (NeuRA)

Researchers:

  • Nicolas Dzamko, PhD

Find out more

ARE THERE PERIPHERAL CHANGES IN GBA PROTEIN/ACTIVITY IN IDIOPATHIC PARKINSON’S DISEASE PATIENTS

Professor Glenda Halliday

Professor Glenda Halliday

Award Date: March 2016

Duration: 2 years

Institution:  Neuroscience Research Australia (NeuRA)

Researchers:

  • Professor Glenda Halliday

Find out more

MEASURING MITOCHONDRIAL RESPIRATION AND STRESS SIGNALLING IN BLOOD CELLS AS BIOMARKERS FOR PARKINSON’S DISEASE

L-R Emma Collin, Professor Paul Fisher, Dr Danuta Loesch-Mdzewska, Ben Young, Dr Sarah Annesley and Associate Professor David Finklestein

Award Date:  July 2015

Duration: 3 years

Institution:  La Trobe University

Researchers:

  • Professor Fisher
  • Dr Sarah Annesley
  • Dr Danuta Loesch-Mdzewska

Under an exciting new funding agreement with Parkinson’s Victoria we will see the Shake It Up component for this specific project shared equally with Parkinson’s Victoria.

Find out more

PHARMCOLOGICAL TARGETING OF THE NLRP3 INFLAMMASOME

Researchers from the University of Queensland.

Associate Professor Woodruff with fellow researchers

Award Date:  December 2014

Duration: 2 years

Institution:  University of Queensland

Researchers:

  • Associate Professor Woodruff

Find out more

 

Past projects

 

LRRK2 AND TYPE-1 INTERFERON

Dzamko2

Dr Nicolas Dzamko

Award Date: July 2014

Duration: 1 year

Institution:  Neuroscience Research Australia (NeuRA)

Researchers:

  • Professor Glenda Halliday
  • Dr Nicolas Dzamko

Find out more

 

 

VERIFICATION OF A LONG-NONCODING RNA IN BLOOD AS A BIOMARKER

Anthony Cooper - Garvan Institute

Associate Professor Antony Cooper

Award Date:  June 2014

Duration:  1 year

Institution:   Garvan Institute for Medical Research

Researchers:

  • John Mattick
  • Antony Cooper

Find out more

 

 

EFFECT OF LRRK2 MUTATIONS ON PD ASSOCIATED INFLAMMATION

Professor Glenda Halliday

Professor Glenda Halliday

Award Date:  February 2014

Duration:  1 year

Institution:  Neuroscience Research Australia (NeuRA)

Researchers:

  • Professor Glenda Halliday
  • Dr Nicolas Dzamko

Find out more

 

 

A BIOMARKER TEST FOR LRRK2 BLOCKING DRUGS

Professor Glenda Halliday and Dr Nicolas Dzamko

Professor Glenda Halliday and Dr Nicolas Dzamko

Award Date:  October, 2013

Duration:  1 year

Institution:  Neuroscience Research Australia (NeuRA)

Researchers:

  • Professor Glenda Halliday
  • Dr Nicolas Dzamko

Find out more

 

 

PARKINSON’S PROGRESSION MARKERS INITIATIVE (PPMI)

Professor Dominic Rowe

Professor Dominic Rowe

Award Date: April 2012

Duration:  5 years

Institution:  Macquarie Neurology at Macquarie University Clinic,  Macquarie University, Sydney, NSW

Researcher

  • Professor Dominic Rowe

Find out more

 

 

 

THE ROLE OF LONG NON-CODING RNAs IN PARKINSON’S DISEASE

Professor John Mattick

Professor John Mattick

Award Date:  September, 2013

Duration:  1 year

Institution:   Garvan Institute for Medical Research

Researchers:

  • John Mattick
  • Antony Cooper

Find out more

 

 

 LRRK2 EXPRESSION IN POST MORTEM BRAIN

DSC_9080

Professor Glenda Halliday and Dr Nicolas Dzamko

Award Date:  September 2013

Duration:  18 month

Institution:  Neuroscience Research Australia (NeuRA)

Researchers:

  •  Prof Glenda Halliday
  • Dr Nic Dzamko

Find out more

 

 

IMPROVING THERAPEUTIC TARGETING OF DOMPAMINERGIC AFFERENTS

Dr Catherine Leamey, Dr Atomu Sawatari

Award Date:  June 2013

Duration:  1 year

Institution:   University of Sydney

Researchers:

  • Atomu Sawatari
  • Catherine Anne Leamey

Find out more

 

 

ALPHA-SYNUCLEIN AS A MAJOR REGULATOR OF IRON

Associate Professor David Finklestein

Associate Professor David Finklestein

Award Date: October 2012

Duration:  2 years

Institution: Florey Institute for Neuroscience and Mental Health,

 

Researchers:

  • Scott Ayton, PhD, Melbourne , Australia
  • David I. Finkelstein, PhD Melbourne , Australia
  • Ashley I. Bush, MD/PhD Melbourne , Australia

Find out more

 

 

IS THE XENOMITOCHONDRIAL MOUSE AN ‘IDEAL’ PD MODEL

Dr Ian Andrew Trounce

Dr Ian Andrew Trounce

Award Date: March 2012

Duration: 1 year

Researchers:

  •  Ian Andrew Trounce, PhD – Center for Eye Research Australia
  • Zane Andrews, PhD -Neuronal Metabolism and Degeneration Lab
  • David Moses MD, FRACP -Department of Clinical Neuroscience and Neurological Research

Find out more

 

 

LRRK2 PHYSIOLOGY IN PARKINSON’S DISEASE

Professor Glenda Halliday and Dr Nicolas Dzamko

Professor Glenda Halliday and Dr Nicolas Dzamko

Award Date:   November 2011

Duration: 1 year

Institution:  Neuroscience Research Australia (NeuRA)

Researchers:

  •  Prof Glenda Halliday
  • Dr Nic Dzamko

Find out more

 

 

Donate to Parkinson's Research

For further information on our research projects please contact us at enquiries@shakeitup.org.au or call us on 1300 361 803

Our People

CEO

Clyde Campbell , Founding Director

Leadership Team

Vicki Miller – General Manager, Strategic Partnerships

 

Names of Board Members

Clyde Campbell

Greg Campbell

Ben Young

Rick Crethar

Tony Dormer

Andy Mulchay

Jenny Hosie

Graeme Fear

Noel Holmes

Number of Employees

2

Number of Volunteers

2

Registration Information

ABN

65 270 391 304

Tax Deductible

Yes

How to help us

Wills and Bequests

HOW TO LEAVE A GIFT IN YOUR WILL

Leaving a gift in your Will is simple and easy and 100% of your contribution will be directed to research. If you don’t have a Will, you should seek legal advice on creating one.

A gift can be made in the form of specific dollar amounts, a percentage of the estate, or all or a portion of what remains after you have provided for your family.

To leave a gift to Shake It Up in your Will, we suggest the following wording for you and your legal advisor to consider:

I GIVE [$……………….] or [my whole Estate] or [the residue of my Estate] to SHAKE IT UP AUSTRALIA FOUNDATION ABN 65 270 391 304 but in the event that gift can not take effect I DIRECT my Executors in their discretion to give my gift to another charitable organisation in Australia which my Executors consider most closely reflects the objectives of SHAKE IT UP AUSTRALIA FOUNDATION.

Your gift will advance medical research targeted at finding the cure for Parkinson’s so that we can get to the day that this in discriminative disease is eliminated from everyone’s lives.

For more information on how to leave a gift to Shake It Up in your Will or to notify us that you have done so, please contact Vicki Miller on 1300 361 803 or via email at vicki@shakeitup.org.au.

General Donations

Make a donation to Parkinson’s research

100% of all donations are directed in Australian Parkinson’s research targeted at better treatments and ultimately a cure.

Thanks to our founding directors covering all administration and overhead costs of the foundation your donation is making a real difference.

Other support

Fundraise for Parkinson’s

Host your own Event

A great way to show your support and to join the fight to cure Parkinson’s is to create your own fundraising event for Shake It Up. Those that host their own event are instrumental in raising both funds and awareness for Parkinson’s research.

Participate in an Athletic Event

It’s simple to get involved – just register for an event, create a fundraising page and ask your friends and family to support you.

 

Work with us

Volunteer with us

Shake Things Up and register to volunteer

With the Founding Directors guaranteeing 100% of all funds received are invested into research, we need to ensure overheads are kept low and there’s no hidden operational costs to take away from our goal of finding the cure.

If you want to help make a difference and help celebrate our successes and achievements with us, there’s so many ways you can offer your time …

  • Events – there’s always an operational component where we need some help on event day, if you can spare a few hours, why not get involved!
  • Graphic Design Skills – We are always looking for volunteers who can provide their design skills to assist with graphics for our events, invitations, brochures and website.

  • Video Editing – Shake It Up has been fortunate to have some wonderful videos completed Pro-Bono.   If you would like to volunteer your skills in this area we would love to hear from you.

 

Shake It Up Australia Foundation would like to extend a huge ‘thank you!’ to our many volunteers who have given their time and represented the Foundation with integrity and pride – we couldn’t have done it without you!
THOSE WHO CAN, DO.
THOSE WHO CAN DO MORE, VOLUNTEER.

Our Mission / Objective

Shake It Up Australia Foundation is a not-for-profit organisation established in 2011 and in partnership with The Michael J. Fox Foundation (MJFF) promotes and funds Parkinson’s disease research in Australia aimed at better treatments and ultimately a cure.

The foundation was established by Clyde Campbell, a father of three and business owner who was diagnosed with Parkinson’s disease in 2009 at the age of 44.

To date the foundation has co-funded over $10.4 Million into Australia Research projects targeted at finding better treatments and ultimately a cure for Parkinson’s.

Most of the projects we support are funded on a 50/50 basis with The Michael J. Fox Foundation which means that we are effectively able to double the reach of the funds we raise.

Together with our partners The Michael J. Fox Foundation, we are the largest non-government funders of Parkinson’s research across multiple institutes in Australia.  It is only through international collaboration that we will find a cure for Parkinson’s.

Our Services

As the country’s leader in strategic Parkinson’s research funding we are excited about the talent we have in our Australian institutes and the prospect that their work will take us closer to a cure.

OUR FUNDING MODEL
100% of your donation goes to Parkinson's research

  • 100% of your donation goes to research targeted at finding better treatments and ultimately a cure for Parkinson’s disease.

(This is made possible by our founding directors’ commitment to fund all administration costs of the foundation)

  • Our partnership with the Michael J. Fox Foundation for Parkinson’s Research ensures efficiency and transparency.
    Key benefits to our research grants are:
  • Internationally Competitive
  • Non Redundant
  • Strategically Managed

Our Beneficiaries

Our partnership with MJFF gives confidence that the research we are funding in Australia is internationally competitive. All funded research is first assessed and validated by the expert panel of scientists at MJFF to eliminate redundancy of research around the globe. Once approved the research projects are monitored and benchmarked by a team of formally trained PhDs and business-trained project managers. This includes the periodic release of funds in line with the approved grant and on the basis of reported results.

Shake It Up have funded projects at:

  • The Garvan Institute for Medical Research
  • Neuroscience Research Australia (NEURA)
  • The  University of Sydney
  • Brain and Mind Institute
  • Macquarie Neurology
  • The Florey Institute
  • La Trobe University
  • University of Queensland

Projects in Progress

As the country’s leader in strategic Parkinson’s research funding we are excited about the talent we have in our Australian institutes and the prospect that their work will take us closer to a cure.

Through our unique partnership we know our research is strategic, non-redundant and internationally competitive. Listed below are the projects we have funded and with your support we look forward to funding many more in the future.

Current projects

 

Linked Clinical Trial – NSW

Professor Simon Lewis

Professor Simon Lewis

Award Date: April 2018

Duration: 3 Years

Institution:  Brain and Mind Institute,  University of Sydney

Researchers:

  • Professor Simon Lewis, Professor Dominic Rowe, Professor Glenda Halliday

 

The protocol for this trial will be  for four drugs and one placebo in patients with more established Parkinson’s as well as validating disease biomarkers that could be used to evaluate the efficacy of future therapeutic treatments

Linked Clinical Trial – Queensland

Associate Professor John O'Sullivan

Associate Professor John O’Sullivan

Award Date: April 2018

Duration: 3 Years

Institution:  The University of Queensland

Researchers:

  • Associate Professor John O’Sullivan

This project is a collaboration between the University of Queensland, Shake It Up, Queensland Government, The Wesley Research Institute, Griffith University and The Cure Parkinson’s Trust.

The protocol for this study is to trial two re-purposed drugs against two placebo groups. The overall approach of the intended trial is to rapidly screen existing drugs that are licensed and used already in clinical practice for other indications to determine whether they are worth transitioning to Phase III, multi-centre, randomised, placebo-controlled, double blind trials. If successful, such trials would facilitate a change in the indication of already licensed medications to allow their use as disease modifying treatments for Parkinson’s disease.

 

Using MJF-14 antibody to uncover novel alpha-synuclein pathology in Parkinson’s disease and MSA

Professor Glenda Halliday phD

Award Date: December 2017

Duration: 2 Years

Institution:  The University of Sydney

Researchers:

  • Professor Glenda Halliday phD

I) Assess the presence of aggregated alpha-synuclein in inclusions and as diffuse oligomers in PD (Braak stage 4 and 6) and MSA (MSA-p and MSA-C) post-mortem tissues by IHC and IF using
multiple antibodies selected for alpha-synuclien including MJF-14
2) Assess the presence of aggregated alpha-synuclein in inclusions and as diffuse oligomers in PD and MSA post-mo1iem tissues by MJF-14 proximity ligation assay and fF analyses
3) Assess the correlation between the cytopathology of oligodendrocytes, astrocytes and neurons
4) Assess specific protein changes associated with inclusion formation, myelination and mitochondria

Objective Measurement for population screening therapy optimisation and target validation

Professor Malcolm Horne

Award Date: December 2017

Duration: 2 Years

Institution:  Florey Neurosciences Institute

Researchers:

  • Professor Malcolm Horne

Objective measurement in Parkinson’s Disease (PD), offers significant advantages for clinical management and the clinical validation of new therapies.

The Parkinson’s/Personal KinetiGraph™ (PKG™) System provides continuous, objective measurement of movement disorder symptoms in everyday environments, including bradykinesia (BK), dyskinesia (DK) and tremor. The PKG™ system consists of a wearable data logger, proprietary algorithms for data analyses and
intuitive data presentation for clinicians (the PKG™ report). The PKG system was TGA Registered in 2009, CE Marked in 2010, and FDA cleared in 2014.

This project seeks to demonstrate that the use of targets will identify PwP with uncontrolled motor features of PD and that treating these subjects according to Treatment Guidelines will bring these scores into target and lead to better clinical and quality of life outcomes. Treatment Guidelines are a critical tool to assist non-specialist clinicians, such as general neurologists and geriatricians, to more effectively manage PD.

Validation of these treatment targets will also advance the evidence-based application of objective measurement and targets for clinical validation of new therapies.

How Does LRRK2 Activity Affect Inflammatory Signaling in Parkinson’s Disease?

Nic Dzamko - University of Sydney Parkinson's research

Dr Nicolas Dzamko PhD – University of Sydney

Award Date: February 2017

Duration: 12 months

Institution:  The University of Sydney

Researchers:

  • Dr Nicolas Dzamko PhD

Differences in the leucine-rich repeat kinase 2 (LRRK2) gene can increase the risk of developing Parkinson’s disease (PD), and there is an abundance of the LRRK2 protein in blood immune cells that regulate inflammation. This project will determine if genetic differences in LRRK2 affect inflammation in PD.

Find out more

Peripheral Inflammatory Cytokine Profiling in Parkinson’s Disease

Nic Dzamko - University of Sydney Parkinson's research

Dr Nicolas Dzamko PhD – University of Sydney

Award Date: February 2017

Duration: 12 months

Institution:  The University of Sydney

Researchers:

  • Dr Nicolas Dzamko PhD

The contribution of inflammation to Parkinson’s disease (PD) is increasingly being recognised. However, the stage of the disease in which inflammation is prevalent and/or important remains unclear. Our recent work suggests that inflammation may be increased early in the course of PD.

Find out more

Pharmacological Targeting of Proinflammatory Kinase Signaling in Parkinson’s Disease

Dr Richard Gordon research into Parkinson's disease

Dr Richard Gordon

Award Date: November 2016

Duration: 12 months

Institution:  UQ’s School of Biomedical Sciences

Researchers:

  • Dr Richard Gordon

The research collaboration comprises researchers from across UQ, including Dr. Richard Gordon and Associate Professor Woodruff from the School of Biomedical Sciences, Dr John O’Sullivan from The School of Medicine and RBWH and Professor Matt Cooper and Dr Kate Schroder from the Institute for Molecular Bioscience.

Find out more

Blocking Inflammasome-induced Neuroinflammation in Parkinson’s Disease with a Potent, Orally Available Small Molecule

Matthew Cooper - receives funding from Shake It Up for Parkinson's research

Matthew Cooper, PhD

Award Date: September 2016

Duration: 12 months

Institution:  NHMRC Principal Research Fellow and Professor of Chemistry & Structural Biology at University of Queensland

Researchers:

  • Matthew Allister Cooper, PhD

Find out more

FLUROSCENCE TAGGING OF ENDOGENOUS LRRK2 TO ENABLE IN VIVO IMAGING IN MICE AND DIFFERENTIATED HUMAN IPS CELLS

Dzamko2

Dr Nicolas Dzamko

Award Date: March 2016

Duration: 12 months

Institution:  Neuroscience Research Australia

Researchers:

  • Nicolas Dzmako

Find out more

DEVELOPMENT OF A NOVEL TRACER FOR IMAGING A-SYNUCLEIN IN VIVO

Victor Villemagne

Award Date: March 2016

Duration: 12 months

Institution:  The Florey Institute of Neuroscience and Mental Health

Researchers:

  • Victor Villemagne, MD
  • Kevin Barnham, PhD

Find out more

UNDERSTANDING LRRK2 S910/S935 PHOSPHORYLATION IS IMPORTANT FOR THERAPEUTIC LRRK2 INHIBITOR DEVELOPMENT.

Dzamko2

Dr Nicolas Dzamko

Award Date: March 2016

Duration: 12 months

Institution:  Neuroscience Research Australia (NeuRA)

Researchers:

  • Nicolas Dzamko, PhD

Find out more

ARE THERE PERIPHERAL CHANGES IN GBA PROTEIN/ACTIVITY IN IDIOPATHIC PARKINSON’S DISEASE PATIENTS

Professor Glenda Halliday

Professor Glenda Halliday

Award Date: March 2016

Duration: 2 years

Institution:  Neuroscience Research Australia (NeuRA)

Researchers:

  • Professor Glenda Halliday

Find out more

MEASURING MITOCHONDRIAL RESPIRATION AND STRESS SIGNALLING IN BLOOD CELLS AS BIOMARKERS FOR PARKINSON’S DISEASE

L-R Emma Collin, Professor Paul Fisher, Dr Danuta Loesch-Mdzewska, Ben Young, Dr Sarah Annesley and Associate Professor David Finklestein

Award Date:  July 2015

Duration: 3 years

Institution:  La Trobe University

Researchers:

  • Professor Fisher
  • Dr Sarah Annesley
  • Dr Danuta Loesch-Mdzewska

Under an exciting new funding agreement with Parkinson’s Victoria we will see the Shake It Up component for this specific project shared equally with Parkinson’s Victoria.

Find out more

PHARMCOLOGICAL TARGETING OF THE NLRP3 INFLAMMASOME

Researchers from the University of Queensland.

Associate Professor Woodruff with fellow researchers

Award Date:  December 2014

Duration: 2 years

Institution:  University of Queensland

Researchers:

  • Associate Professor Woodruff

Find out more

 

Past projects

 

LRRK2 AND TYPE-1 INTERFERON

Dzamko2

Dr Nicolas Dzamko

Award Date: July 2014

Duration: 1 year

Institution:  Neuroscience Research Australia (NeuRA)

Researchers:

  • Professor Glenda Halliday
  • Dr Nicolas Dzamko

Find out more

 

 

VERIFICATION OF A LONG-NONCODING RNA IN BLOOD AS A BIOMARKER

Anthony Cooper - Garvan Institute

Associate Professor Antony Cooper

Award Date:  June 2014

Duration:  1 year

Institution:   Garvan Institute for Medical Research

Researchers:

  • John Mattick
  • Antony Cooper

Find out more

 

 

EFFECT OF LRRK2 MUTATIONS ON PD ASSOCIATED INFLAMMATION

Professor Glenda Halliday

Professor Glenda Halliday

Award Date:  February 2014

Duration:  1 year

Institution:  Neuroscience Research Australia (NeuRA)

Researchers:

  • Professor Glenda Halliday
  • Dr Nicolas Dzamko

Find out more

 

 

A BIOMARKER TEST FOR LRRK2 BLOCKING DRUGS

Professor Glenda Halliday and Dr Nicolas Dzamko

Professor Glenda Halliday and Dr Nicolas Dzamko

Award Date:  October, 2013

Duration:  1 year

Institution:  Neuroscience Research Australia (NeuRA)

Researchers:

  • Professor Glenda Halliday
  • Dr Nicolas Dzamko

Find out more

 

 

PARKINSON’S PROGRESSION MARKERS INITIATIVE (PPMI)

Professor Dominic Rowe

Professor Dominic Rowe

Award Date: April 2012

Duration:  5 years

Institution:  Macquarie Neurology at Macquarie University Clinic,  Macquarie University, Sydney, NSW

Researcher

  • Professor Dominic Rowe

Find out more

 

 

 

THE ROLE OF LONG NON-CODING RNAs IN PARKINSON’S DISEASE

Professor John Mattick

Professor John Mattick

Award Date:  September, 2013

Duration:  1 year

Institution:   Garvan Institute for Medical Research

Researchers:

  • John Mattick
  • Antony Cooper

Find out more

 

 

 LRRK2 EXPRESSION IN POST MORTEM BRAIN

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Professor Glenda Halliday and Dr Nicolas Dzamko

Award Date:  September 2013

Duration:  18 month

Institution:  Neuroscience Research Australia (NeuRA)

Researchers:

  •  Prof Glenda Halliday
  • Dr Nic Dzamko

Find out more

 

 

IMPROVING THERAPEUTIC TARGETING OF DOMPAMINERGIC AFFERENTS

Dr Catherine Leamey, Dr Atomu Sawatari

Award Date:  June 2013

Duration:  1 year

Institution:   University of Sydney

Researchers:

  • Atomu Sawatari
  • Catherine Anne Leamey

Find out more

 

 

ALPHA-SYNUCLEIN AS A MAJOR REGULATOR OF IRON

Associate Professor David Finklestein

Associate Professor David Finklestein

Award Date: October 2012

Duration:  2 years

Institution: Florey Institute for Neuroscience and Mental Health,

 

Researchers:

  • Scott Ayton, PhD, Melbourne , Australia
  • David I. Finkelstein, PhD Melbourne , Australia
  • Ashley I. Bush, MD/PhD Melbourne , Australia

Find out more

 

 

IS THE XENOMITOCHONDRIAL MOUSE AN ‘IDEAL’ PD MODEL

Dr Ian Andrew Trounce

Dr Ian Andrew Trounce

Award Date: March 2012

Duration: 1 year

Researchers:

  •  Ian Andrew Trounce, PhD – Center for Eye Research Australia
  • Zane Andrews, PhD -Neuronal Metabolism and Degeneration Lab
  • David Moses MD, FRACP -Department of Clinical Neuroscience and Neurological Research

Find out more

 

 

LRRK2 PHYSIOLOGY IN PARKINSON’S DISEASE

Professor Glenda Halliday and Dr Nicolas Dzamko

Professor Glenda Halliday and Dr Nicolas Dzamko

Award Date:   November 2011

Duration: 1 year

Institution:  Neuroscience Research Australia (NeuRA)

Researchers:

  •  Prof Glenda Halliday
  • Dr Nic Dzamko

Find out more

 

 

Donate to Parkinson's Research

For further information on our research projects please contact us at enquiries@shakeitup.org.au or call us on 1300 361 803

Our People

CEO

Clyde Campbell , Founding Director

Leadership Team

Vicki Miller – General Manager, Strategic Partnerships

 

Names of Board Members

Clyde Campbell

Greg Campbell

Ben Young

Rick Crethar

Tony Dormer

Andy Mulchay

Jenny Hosie

Graeme Fear

Noel Holmes

Number of Employees

2

Number of Volunteers

2

Registration Information

ABN

65 270 391 304

Tax Deductible

Yes

How to Help us

Wills and Bequests

HOW TO LEAVE A GIFT IN YOUR WILL

Leaving a gift in your Will is simple and easy and 100% of your contribution will be directed to research. If you don’t have a Will, you should seek legal advice on creating one.

A gift can be made in the form of specific dollar amounts, a percentage of the estate, or all or a portion of what remains after you have provided for your family.

To leave a gift to Shake It Up in your Will, we suggest the following wording for you and your legal advisor to consider:

I GIVE [$……………….] or [my whole Estate] or [the residue of my Estate] to SHAKE IT UP AUSTRALIA FOUNDATION ABN 65 270 391 304 but in the event that gift can not take effect I DIRECT my Executors in their discretion to give my gift to another charitable organisation in Australia which my Executors consider most closely reflects the objectives of SHAKE IT UP AUSTRALIA FOUNDATION.

Your gift will advance medical research targeted at finding the cure for Parkinson’s so that we can get to the day that this in discriminative disease is eliminated from everyone’s lives.

For more information on how to leave a gift to Shake It Up in your Will or to notify us that you have done so, please contact Vicki Miller on 1300 361 803 or via email at vicki@shakeitup.org.au.

General Donations

Make a donation to Parkinson’s research

100% of all donations are directed in Australian Parkinson’s research targeted at better treatments and ultimately a cure.

Thanks to our founding directors covering all administration and overhead costs of the foundation your donation is making a real difference.

Other support

Fundraise for Parkinson’s

Host your own Event

A great way to show your support and to join the fight to cure Parkinson’s is to create your own fundraising event for Shake It Up. Those that host their own event are instrumental in raising both funds and awareness for Parkinson’s research.

Participate in an Athletic Event

It’s simple to get involved – just register for an event, create a fundraising page and ask your friends and family to support you.

 

Work with us

Volunteer with us

Shake Things Up and register to volunteer

With the Founding Directors guaranteeing 100% of all funds received are invested into research, we need to ensure overheads are kept low and there’s no hidden operational costs to take away from our goal of finding the cure.

If you want to help make a difference and help celebrate our successes and achievements with us, there’s so many ways you can offer your time …

  • Events – there’s always an operational component where we need some help on event day, if you can spare a few hours, why not get involved!
  • Graphic Design Skills – We are always looking for volunteers who can provide their design skills to assist with graphics for our events, invitations, brochures and website.

  • Video Editing – Shake It Up has been fortunate to have some wonderful videos completed Pro-Bono.   If you would like to volunteer your skills in this area we would love to hear from you.

 

Shake It Up Australia Foundation would like to extend a huge ‘thank you!’ to our many volunteers who have given their time and represented the Foundation with integrity and pride – we couldn’t have done it without you!
THOSE WHO CAN, DO.
THOSE WHO CAN DO MORE, VOLUNTEER.

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