Guide to Giving
MEDIA, JOBS & RESOURCES for the COMMON GOOD
News  |  Fundraising

$7M Grant For Alzheimer’s Research


Thursday, 1st September 2016 at 11:38 am
Wendy Williams
A major grant of more than $7 million to help Alzheimer’s research, coinciding with the start of Dementia Awareness Month in Australia, could “unlock the door” to new medicines.

Thursday, 1st September 2016
at 11:38 am
Wendy Williams


0 Comments


FREE SOCIAL
SECTOR NEWS

 Print
$7M Grant For Alzheimer’s Research
Thursday, 1st September 2016 at 11:38 am

A major grant of more than $7 million to help Alzheimer’s research, coinciding with the start of Dementia Awareness Month in Australia, could “unlock the door” to new medicines.

Aged Care Professionals RS

Monash University announced on Wednesday that leading international medical research funding organisation The Wellcome Trust had awarded them £4.2 million (A$7.1 million) towards funding research into treatments for Alzheimer’s and other debilitating neurodegenerative diseases.

The funding will help researchers at Monash Institute of Pharmaceutical Sciences (MIPS) to pursue research aimed at producing more effective, side-effect-free treatments for diseases including Alzheimer’s and schizophrenia.

The grant will also underpin a major collaboration between Professors Patrick Sexton and Arthur Christopoulos at Monash with Professor Andrew Tobin in the Centre for Translational Pharmacology at the University of Glasgow.

Sexton said the funding would enable new research on a family of drug targets called G protein-coupled receptors, or GPCRs.

“GPCRs are well-known to be involved in most human diseases, but many current drug discovery efforts targeting these proteins show alarming failure rates in translating promising preclinical findings to the clinic and onto the market,” Sexton said.

“If we could understand key mechanisms underlying this preclinical-to-clinical translational gap, we would be able to unlock the door to many new medicines.”

The grant will enable world-leading scientists to come together to investigate which molecular features distinguish drugs that act effectively on GPCRs from those that don’t.

Christopoulos said the research would specifically focus on the muscarinic acetylcholine receptors, a GPCR family involved in memory deficits associated with Alzheimer’s disease and schizophrenia.

“Our research suggests that some of the major drivers underlying the failure to translate preclinical GPCR discoveries into the clinic is not because the wrong target has been chosen but, rather, that the wrong approach has been used towards exploiting that target,” Christopoulos said.

“We have discovered that there are far more subtle and innovative ways of selectively targeting GPCRs than most current approaches. These approaches have the potential to yield better drug candidates with a higher chance of clinical efficacy, as well as a reduced propensity for side effects.

“Through the award of this grant, we aim to use our studies of the muscarinic receptor family as a proof of concept that can subsequently be applied to other receptors and disease states.”

 


Wendy Williams  |  Editor  |  @WendyAnWilliams

Wendy Williams is a journalist specialising in the not-for-profit sector and broader social economy. She has been the editor of Pro Bono News since 2018.


Got a story to share?

Got a news tip or article idea for Pro Bono News? Or perhaps you would like to write an article and join a growing community of sector leaders sharing their thoughts and analysis with Pro Bono News readers?

Get in touch at news@probonoaustralia.com.au

Get more stories like this

FREE SOCIAL
SECTOR NEWS

Write a Reply or Comment

Your email address will not be published. Required fields are marked *



YOU MAY ALSO LIKE

Setting Aussie kids up for success

Luke Michael

Wednesday, 5th June 2019 at 4:13 pm

Philanthropy called to step up support of community-led projects

Luke Michael

Wednesday, 29th May 2019 at 11:41 am

A moral dilemma: When philanthropy meets inequality

Wendy Williams

Tuesday, 28th May 2019 at 8:26 am

Philanthropy powerhouses go public with donation to save WA reefs

Maggie Coggan

Monday, 27th May 2019 at 4:35 pm

POPULAR

Charities take fundraising into their own hands

Maggie Coggan

Tuesday, 18th June 2019 at 8:28 am

Why an AAT ruling could shake-up NDIS funding

Luke Michael

Friday, 14th June 2019 at 4:16 pm

UK inquiry finds Oxfam failed to act on child sex abuse claims

Luke Michael

Wednesday, 12th June 2019 at 5:26 pm

Guide to Giving
pba inverse logo
Subscribe Twitter Facebook

Get the social sector's most essential news coverage. Delivered free to your inbox every Tuesday and Thursday morning.

You have Successfully Subscribed!