Close Search
 
MEDIA, JOBS & RESOURCES for the COMMON GOOD
News  |  Fundraising

$7M Grant For Alzheimer’s Research


1 September 2016 at 11:38 am
Wendy Williams
A major grant of more than $7 million to help Alzheimer’s research, coinciding with the start of Dementia Awareness Month in Australia, could “unlock the door” to new medicines.

Wendy Williams | 1 September 2016 at 11:38 am


0 Comments


 Print
$7M Grant For Alzheimer’s Research
1 September 2016 at 11:38 am

A major grant of more than $7 million to help Alzheimer’s research, coinciding with the start of Dementia Awareness Month in Australia, could “unlock the door” to new medicines.

Aged Care Professionals RS

Monash University announced on Wednesday that leading international medical research funding organisation The Wellcome Trust had awarded them £4.2 million (A$7.1 million) towards funding research into treatments for Alzheimer’s and other debilitating neurodegenerative diseases.

The funding will help researchers at Monash Institute of Pharmaceutical Sciences (MIPS) to pursue research aimed at producing more effective, side-effect-free treatments for diseases including Alzheimer’s and schizophrenia.

The grant will also underpin a major collaboration between Professors Patrick Sexton and Arthur Christopoulos at Monash with Professor Andrew Tobin in the Centre for Translational Pharmacology at the University of Glasgow.

Sexton said the funding would enable new research on a family of drug targets called G protein-coupled receptors, or GPCRs.

“GPCRs are well-known to be involved in most human diseases, but many current drug discovery efforts targeting these proteins show alarming failure rates in translating promising preclinical findings to the clinic and onto the market,” Sexton said.

“If we could understand key mechanisms underlying this preclinical-to-clinical translational gap, we would be able to unlock the door to many new medicines.”

The grant will enable world-leading scientists to come together to investigate which molecular features distinguish drugs that act effectively on GPCRs from those that don’t.

Christopoulos said the research would specifically focus on the muscarinic acetylcholine receptors, a GPCR family involved in memory deficits associated with Alzheimer’s disease and schizophrenia.

“Our research suggests that some of the major drivers underlying the failure to translate preclinical GPCR discoveries into the clinic is not because the wrong target has been chosen but, rather, that the wrong approach has been used towards exploiting that target,” Christopoulos said.

“We have discovered that there are far more subtle and innovative ways of selectively targeting GPCRs than most current approaches. These approaches have the potential to yield better drug candidates with a higher chance of clinical efficacy, as well as a reduced propensity for side effects.

“Through the award of this grant, we aim to use our studies of the muscarinic receptor family as a proof of concept that can subsequently be applied to other receptors and disease states.”

 


Wendy Williams  |  Editor  |  @WendyAnWilliams

Wendy Williams is a journalist specialising in the not-for-profit sector and broader social economy. She has been the editor of Pro Bono News since 2018.

PB Careers
Get your biweekly dose of news, opinion and analysis to keep you up to date with what’s happening and why it matters for you, sent every Tuesday and Thursday morning.

Got a story to share?

Got a news tip or article idea for Pro Bono News? Or perhaps you would like to write an article and join a growing community of sector leaders sharing their thoughts and analysis with Pro Bono News readers? Get in touch at news@probonoaustralia.com.au or download our contributor guidelines.

Get more stories like this

FREE SOCIAL
SECTOR NEWS

Your email address will not be published. Required fields are marked *



YOU MAY ALSO LIKE

New grants program to help the hidden victims of COVID-19

Luke Michael

Monday, 27th July 2020 at 4:59 pm

COVID crisis forces a shift in grantmaking

Luke Michael

Friday, 24th July 2020 at 11:48 am

Supporting not for profits to build capacity for impact

Andrew Cairns

Thursday, 23rd July 2020 at 7:10 am

Want to help shape Melbourne?

Contributor

Thursday, 23rd April 2020 at 7:15 am

pba inverse logo
Subscribe Twitter Facebook
×

We need your help.

Since the outbreak of COVID-19, Pro Bono Australia has seen a devastating fall in advertising and less people posting on our job board, which is how we fund our free news service. You can show us that you value the work we do by making a contribution.

 Make a contribution 

You have Successfully Subscribed!